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KMID : 0892920150240020126
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Experimental Neurobiology
2015 Volume.24 No. 2 p.126 ~ p.132
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Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1-/- Mice
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Mah Won
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Abstract
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Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1-/- mice, previously proposed as an animal model for ADHD, show abnormal theta oscillation in the thalamus. Multi-electrode recordings revealed that Git1-/- mice have hyper-synchrony of neural activities between the thalamus and cortex. The abnormal thalamic oscillation and thalamocortical synchrony in Git1-/- mice were markedly reduced by amphetamine. In addition, ethosuximide ameliorates abnormal thalamic oscillation and ADHD-like hyperactivity shown in Git1-/- mice. My study suggests critical roles of GIT1 and thalamocortical neural circuitry in ADHD.
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KEYWORD
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ADHD, GIT1, Thalamic oscillation, Coherence
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